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KMID : 1140120120170040280
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Cancer Prevention Research
2012 Volume.17 No. 4 p.280 ~ p.287
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Leukocytes DNA Damage and Serum Antioxidant Status in Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer Patients
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Seo Bo-Young
Kim Soo-Yeon
Park Eun-Ju
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Abstract
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This study investigated leukocytes DNA damage, serum total radical trapping potential (TRAP), conjugated dienes (CD) and lipid antioxidant vitamins (retinol, α-, γ-tocopherol, α-, β-carotene and coenzyme Q10) in 66 cervical cancer patients (32 with cervical intraepithelial neoplasia [CIN], 34 with invasive cervical cancer [ICC]) and controls (41 normal subjects). CIN and ICC had significantly higher level of endogenous leukocytic DNA damage than the control. Oxidative DNA damage was induced by 200 μM H2O2. Tail length of CIN and ICC were significantly higher than the control. However, the % tail DNA and tail moment showed significantly different between control and ICC while the levels of CIN were not shown significant. TRAP level was significantly decreased in ICC compared to the control. Significantly higher level of serum CD was found both in CIN and ICC compared to the control. The concentrations of lipid antioxidant vitamins were significantly lower in the CIN and ICC than in the control. The status of serum lipid peroxidation showed significant positive correlation with the leukocytic DNA damage. The results of the current study suggested the involvement of lipid peroxidation, impaired serum antioxidant system and leukocytic DNA damage in the pathogenesis of cervical dysplasia.
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KEYWORD
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Cervical carcinoma, Leukocytes DNA damage, Antioxidant, Lipid peroxidation
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